Conference Abstracts and Non-Peer Reviewed Papers

Move Year Wise 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 2007 | 2008 | 2009 | 2010 | 2011 | 2012 | 2013 | 2014 | 2015 | 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | 2023 | 2024

  • 2000

  • Thornalley, P.J., Jahan, I., Ahmed, N. and Ng, R. (2000) The putative antiglycation agent phenacylthiazolium bromide suppresses cellular triosephosphate accumulation in model hyperglycaemia in vitro by stimulating the pentosephosphate pathway to consume glyceraldehyde-3-phosphate and produce ribose-5-phosphate. Diabetes 49, Suppl. 1, A150
  • Abordo, E.A., Ahmed, N., Limb, G.A., Argirov, O.K. and Thornalley, P.J. (2000) Increased plasma protein methylglyoxal-derived advanced glycation endproducts in IDDM subjects with retinopathy. Diabetic Medicine 17, Suppl. 1, 33. (Abstract).
  • Ahmed, N. and Thornalley, P.J. (2000) Advanced glycation endproducts in serum albumin glycated by methylglyoxal and glucose in vitro. Endocrinol & Diabetes 108, A1-A2.

  • 2001

  • Ahmed, N., Thornalley, P.J., Franke, S, Stein, G. and Dawczynski, J. (2001) Fluorescent advanced glycation endproducts, argpyrimidine and pentosidine, in lens proteins of diabetic and healthy control human subjects. Diabetologia 44, Suppl. 1, A34 (Abstract)

  • 2002

  • Ahmed, N., Haik, G.M. Jr. and Thornalley, P.J. (2002) Hemoglobin glycated by methylglyoxal AGE-HbMG-H1 in type 1 diabetic subjects and relation to glycemic control. Diabetes 51, Suppl. 2, A118 (Abstract)
  • Ng, R., Argirov, O.K., Ahmed, N., Weigle, B. and Thornalley, P.J. (2002) Human serum albumin minimally modified by methylglyoxal binds to human mononuclear leukocytes via the RAGE receptor and is displaced by Ne-carboxymethyl-lysine and hydroimidazolone AGE epitopes. The Maillard Reaction in Food Chemistry and Medical Science: Update for the Postgenomic Era, Excerpta Medica International Congress Series 1245 (Horiuchi S., Taniguchi T., Hayase F., Kurata T. and Osawa T. eds.), 77-81.
  • Battah, S., Ahmed, N. and Thornalley, P.J. (2002) Kinetics and mechanism of the reaction of metformin with methylglyoxal. The Maillard Reaction in Food Chemistry and Medical Science: Update for the Postgenomic Era, Excerpta Medica International Congress Series 1245 (Horiuchi S., Taniguchi T., Hayase F., Kurata T. and Osawa T. eds.), 255-356.
  • Battah, S., Ahmed, N. and Thornalley, P.J. (2002) Novel anti-glycation therapeutic agents: glyoxalase I mimetics. The Maillard Reaction in Food Chemistry and Medical Science: Update for the Postgenomic Era, Excerpta Medica International Congress Series 1245 (Horiuchi S., Taniguchi T., Hayase F., Kurata T. and Osawa T. eds.), 107-111.
  • Ahmed, N. and Thornalley, P.J. (2002) Assay of early and advanced glycation endproducts by enzymatic hydrolysis of proteins and HPLC of 6-quinolylaminiocarbonyl (AQC) adducts. The Maillard Reaction in Food Chemistry and Medical Science: Update for the Postgenomic Era, Excerpta Medica International Congress Series 1245 (Horiuchi S., Taniguchi T., Hayase F., Kurata T. and Osawa T. eds.), 279-283.
  • Jono,T., Nagai, R., Miyazaki, K., Ahmed, N., Thornalley, P.J., Kitamura, T. and Horiuchi,S. (2002) Detection of 3-deoxyglucosone-derived AGE structures in vivo. The Maillard Reaction in Food Chemistry and Medical Science: Update for the Postgenomic Era, Excerpta Medica International Congress Series 1245 (Horiuchi S., Taniguchi T., Hayase F., Kurata T. and Osawa T. eds.), 239-242.

  • 2003

  • Ahmed, N., Thornalley, P.J., Howell, S.K. and Beisswenger, P.J. (2003) Effect of Postprandial hyperglycemia on advanced glycation endproducts. Diabetes 52, Suppl. 1, A441
  • Ahmed, N.M., Portero-Otin, Manuel, Haik Jr., G.M. and Thornalley, P.J. (2003) Methylglyoxal and methylglyoxal-derived advanced glycation endproducts of hemoglobin in type 1 diabetes with and without retinopathy. Diabetes 52, Suppl. 1, A198
  • Karachalias, N., Babaei-Jadidi, R., Ahmed, N. and Thornalley, P.J. (2003) Quantitative comprehensive screening of advanced glycation endproducts reveals the selective accumulation of hydroimidazolone AGEs in the diabetic retina Diabetes 52, Suppl. 1, 23-LB
  • Lucas, A.J., Karachalias, N., Ahmed, N. and Thornalley, P.J. (2003) High concentrations of advanced glycation endproducts in cellular protein. Link
  • Amajuoyi, I.K., Ahmed, N., Watts, R. and Thornalley, P.J. (2003) High levels of free advanced glycation endproducts in synovial fluid in arthritis. Link
  • Ahmed, N., Hou, Y. and Thornalley, P.J. (2003) Peptide mapping of human serum albumin modified minimally by methylglyoxal. Link
  • Ahmed, N., Battah, S., Karachalias, N., Babaei-Jadidi, R., Horányi, M., Baróti, M., Hollan, S., and Thornalley, P.J. (2003) Increased formation of methylglyoxal and protein glycation, oxidation and nitrosation in triosephosphate isomerase deficiency. Link
  • Karachalias, N., Babaei-Jadidi, R., Ahmed, N.M., Battah, S. and Thornalley, P.J. (2003) High dose thiamine therapy suppresses the accumulation of advanced glycation endproducts and oxidative biomarkers in the glomeruli of streptozotocin-induced diabetic rats on insulin maintenance therapy. Diabetologia 46, Suppl. 2, A405 (Abstract)
  • Ahmed, N.M., Portero-Otin, Manuel, Haik Jr., G.M. and Thornalley, P.J. (2003) Oxidative markers in plasma protein and hemoglobin subjects with type 1 diabetes with and without background and proliferative retinopathy. Diabetes Metab. 29, 4S344 (Abstract)
  • Ahmed, N. and Thornalley, P.J. (2003) Application of LC-MS/MS for the quantitation of glycation, oxidation and nitrosation adducts. Biochem. Soc. Trans. 31, 1417–1422.
  • Karachalias, N., Babaei-Jadidi, R., Ahmed, N. and Thornalley, P.J. (2003) Accumulation of fructosyl-lysine and advanced glycation endproducts in the kidney, retina and peripheral nerve of streptozotocin-induced diabetic rats. Biochem. Soc. Trans.31, 1423-1425
  • Agalou, S., Ahmed, N., A. Dawnay and Thornalley, P.J. (2003) Removal of advanced glycation end products in clinical renal failure by peritoneal dialysis and haemodialysis. Biochem. Soc. Trans. 31, 1394–1396.

  • 2004

  • Morcos, M., Sayed, A., Pfisteer, F., Hutter, H., Thornalley, P., Ahmed, N., Miftan, N., Muhrlen, F., Hamman, A., Bierhaus, A. and Nawroth, P. (2004) Glyoxalase-I als endogener schutz vor advanced glycation end producy (AGE) formation und oxidativen stress in Caenorhabditis elegans. Diabetes und Stoffwechsel 13, 33 (abstract).
  • Thornalley, P.J., Kupich, C., Babaei-Jadidi, R., Karachalias, N. and Ahmed, N. (2004) Thiamine dose thiamine counters diabetic dyslipidemia. Diabetologia 47, suppl. 1, A413.

  • 2005

  • Babaei-Jadidi, R., Karachalias, N., Ahmed, N. and Thornalley, P.J. (2005) Reversal of metabolic dysfunction of human mesangial cells in hyperglycaemia in vitro by thiamine and Benfotiamine. Diabetic Med. 22, Suppl. 2, 22.
  • Karachalias, N., Babaei-Jadidi, R., Ahmed, N., Baynes, K. and Thornalley, P.J. (2005) Urinary D-lactate as a marker of biochemical dysfunction linked to the development of diabetic microvascular complications. Diabetic Med. 22, Suppl. 2, 21.
  • Ahmed, N., Babaei-Jadidi, R., Howell, S.K., Thornalley, P.J. and Beisswenger, P.J. (2005)Dicarbonyl derived AGEs are decreased by reducing postprandial glucose levels. Diabetes 54, Suppl. 1, A513.
  • Morcos, M., Du, X., Sayed, A.A.R., Hutter, H., Pfisterer, F., Thornalley, P.J., Baynes, J., Thorpe, S., Abd El Baki, R., Ahmed, N., Miftari, N., Stern, D., Schlotterer, A., Möhrlen, F., Hamann, A., Becker, C., Humpert, P., Hammes, H.P., Büchler, M., Bierhaus, A., Brownlee, M., Nawroth P.P. (2005) Life extension in Caenorhabditis elegans by overexpression of Glyoxalase I – the connection to protein damage by glycation, oxidation and nitration. Free Radical Res. 39, Suppl. 1, S43.
  • Ahmed, N., Babaei-Jadidi, R, Howell, S.K., Beisswenger, P. and Thornalley, P.J. (2005) Nitrosation of plasma protein and haemoglobin in type 1 diabetes – evidence for compartmentalized action of peroxynitrite in blood physiologically. Free Radical Res. 39, Suppl. 1, S81.
  • Babaei-Jadidi, R., Karachalias, N., Ahmed, N. and Thornalley, P.J. (2005) Prevention of incipient nephropathy by high dose thiamine and Benfotiamine in streptozotocin-induced diabetic rats: effect on markers of oxidative stress. Free Radical Res. 39, Suppl. 1, S81.
  • Song, L., Ahmed, N. and Thornalley, P.J. (2005) Concentrations of dietary isothiocyanates in plasma after consumption of raw broccoli by healthy human subjects. Free Radical Res. 39, Suppl. 1, S87.
  • Chen, Y., Ahmed, N. and Thornalley, P.J. (2005) Peptide mapping of human hemoglobin modified minimally by methylglyoxal in vitro. Ann. N.Y. Acad. Sci. 1043, 905.
  • Dobler, D., Ahmed, N. and Thornalley, P.J. (2005) Peptide mapping of type IV collagen modified minimally by methylglyoxal in vitro. Ann. N.Y. Acad. Sci. 1043, 906.
  • Agalou, S., Ahmed, N., Dawnay, A. and Thornalley, P.J. (2005) Advanced glycation endproduct excretion rates by peritoneal dialysis in end stage renal disease. Ann. N.Y. Acad. Sci. 1043, 921.
  • Ahmed, N., Babaei-Jadidi, R., Thornalley, P.J., Howell, S.K. and Beisswenger, P.J. (2005) Increased plasma and urinary methylglyoxal-derived hydroimidazolone in type 1 diabetic patients. Ann. N.Y. Acad. Sci. 1043, 928.
  • Ahmed, N., Ahmed, U., Hager, K., Fleischer, G., Münch, G. and Thornalley, P.J. (2005) Protein glycation marker residues and free adducts of cerebrospinal fluid in Alzheimer’s disease and link to cognitive impairment. Ann. N.Y. Acad. Sci. 1043, 914.
  • Kennish, L., Dobler, D., Ahmed, N. and Thornalley, P.J. (2005) Protein glycation and oxidation in cola and pasteurised milk. Ann. N.Y. Sci. 1043, 907.
  • Berlanga, J., Cibrian, D., Guillén, I., Freyre, F., Alba, J.S., Merino, N., Aldama, A., Quintela, A.M., Triana, M.E., Ajameich, H., Lopez, P., Ahmed, N. and Thornalley, P.J. (2005) Exogenous methylglyoxal induces diabetes-like microvascular changes in rats. Ann. N.Y. Acad. Sci. 1043, 918.
  • Agalou, S, Ahmed, N, Thornalley, P.J. and Dawnay, A. (2005) Advanced glycation endproduct free adducts are cleared by dialysis. Ann. N.Y. Acad. Sci. 1043, 922.
  • Ahmed, N., Karachalias, N., Babaei-Jadidi, R., Thornalley, P.J. (2005) Degradation products of proteins damaged by glycation and oxidation increase markedly in experimental diabetes and are suppressed by high dose therapy with thiamine and Benfotiamine. Diabetologia 48, Suppl. 1, A417 – A418
  • Dobler, D., Ahmed, N. and Thornalley, P.J. (2005) Peptide mapping of type IV collagen modified minimally by methylglyoxal in vitro reveals mechanism of cell-matrix disruption. Internat. J. Exp. Pathol. 86, A83-A84
  • Ahmed, N., Sebekova, K., Sebekova Jr, K., Heidland, A., and Thornalley, P.J. (2005) Effect of bilateral nephrectomy and ureteral ligation on circulating levels of advanced glycation end products in the rat. J. Amer. Soc. Nephrol. 16, 803A.
  • Thornalley, P.J., Schupp, N., Ahmed, N., Braun, J., Vienken, J., Stopper, H., and Heidland, A. (2005) Protein glycation, oxidation and nitration residues in plasma proteins and free adducts in uremia: Effect of hemodiafiltration and hemodialysis. J. Amer

  • 2006

  • Babaei-Jadidi, R., Al-Ali, H., Ahmed, N., Song, L., Ahmed, A., Bodmer, C. and Thornalley, P.J. (2006) Plasma thiamine deficiency in type 1 and type 2 diabetic patients in the United Kingdom with and without microalbuminuria. Diabetic Med. 23 (Suppl. 2), 48. WINNER OF ELI LILLY CLINICAL SCIENCE POSTER AWARD
  • Ahmed, N., Ahmed, U., Thornalley, P.J., Watts, R., Tarr, J., Haigh, R. and Winyard, P. (2006) Profound increase in proteolytic products of glycated and oxidised proteins in synovial fluid and plasma in osteoarthritis and rheumatoid arthritis, corrected by TNF-α antibody therapy in rheumatoid arthritis. Rheumatology 45, Suppl. 1, i53.
  • Qian, Q., Babaei-Jadidi, R., Ahmed, N and Thornalley, P.J. (2006) Reversal of biochemical dysfunction in endothelial cells in hyperglycemia by induction of antioxidant response element-linked gene expression by sulforaphane. Diabetes 55, Suppl. 1, A184-A185.

  • 2007

  • Morcos, M., Du, X., Sayed, A.A.R., Hutter,H,Pfisterer, F., Kukudov, G., Thornalley, P.J., Baynes, J., Thorpe, S., Abd El Baki, R., Rabbani, N., Stern, D., Schlotterer, A., Möhrlen, F., Humpert,P.,Hammes, H.P., Büchler, M., Bierhaus, A., Brownlee, M., Nawroth, P.P. (2007) Life extension in Caenorhabditis elegans by overexpression of Glyoxalase I – a mechanistic integration of protein damage by glycation, oxidation and nitration. Comp. Biochem. Physiol. 146A, S59.
  • Antonysunil, A.K., Babaei-Jadidi, R., Rabbani, N., Ahmed, A., Rayman, G., Bodmer, C.W. and Thornalley, P.J. (2007) Increased Thiamine Transporter Contents of Red Blood Cells and Peripheral Blood Mononuclear Leukocytes in Type 1 and Type 2 Diabetic Patients. Diabetes 56, A609.
  • Rabbani, N. and Thornalley, P.J.(2007) Quantitation of glycation adducts in HDL by liquid chromatography with tandem mass spectrometric detection. Atherosclerosis 8, Suppl 1, 35.
  • Dobler, D., Rabbani, N. and Thornalley, P.J. (2007) Functional impairment of type IV collagen by arginine-directed and not by lysine- directed advanced glycation. http://dfa.leb.chemie.tu-muenchen.de/maillard/ismr9_program_index, BM35
  • Rabbani, N., Dobler, D., and Thornalley, P.J. (2007) Improved assay methodology for assay of dicarbonyls in physiological systems using LC-MS/MS with isotopomer internal standardisation. http://dfa.leb.chemie.tu-muenchen.de/maillard/ismr9_program_index, BM24

  • 2008

  • Perkins, B., Rabbani, N., Weston, A., Adaikalakoteswari, A., Ficociello, L., Warram, J., Krolewski, A.S., Thornalley, P.J. (2008) Early Renal Function Decline in Type 1 Diabetes is Associated with Excess Urinary Excretion of Markers of Protein Damage. Diabetes 57, A210-A210
  • Antonysunil, A., Perkins, B., Krolewski, A., Rabbani, N., Thornalley, P.J. (2008) Thiamine status and risk of early renal function decline in type 1 diabetic patients. Diabetologia 51, S98-S98
  • Rabbani, N. and Thornalley, P.J. (2008) Increased protein damage by advanced glycation endproducts and oxidation adducts in low density lipoprotein of type 2 diabetic patients. Diabetologia 51, S525-S525.
  • Xue, M., Thornalley, P.J. and Rabbani, N. (2008) LDL glycated by methylglyoxal to physiological extent in vitro has increased binding of proteoglycan without impairment of LDL receptor binding. Diabetologia 51, S299-S299.

  • 2009

  • Karachalias, N., Babaei-Jadidi, R., Rabbani, N., and Thornalley, P.J. (2009) Prevention of advanced glycation endproduct accumulation in renal glomeruli, retina and nerve in experimental diabetes by high dose thiamine and Benfotiamine. Diabetic Medicine, 26 (Suppl. 1), 70.
  • Yamada-Fowler, N., Godfrey, L., Thornalley, P.J. and Rabbani, N. (2009) Quantitation of the glycation-induced changes in HDL2 and HDL3 by liquid chromatography with tandem mass spectrometric detection. Diabetic Medicine, 26 (Suppl. 1), 70.
  • Thornalley, P., Xue, M., Rabbani, N. (2009) Involvement of transcription factor nrf2 and antioxidant response element linked gene expression in countering oxidative stress in diabetes. FEBS Journal 276, 79 – 80.
  • Stoyanov, S.B., Fleming, T., Humpert, P.M., Sauer, S., Rabbani, N., Edelstein, D., Thornalley, P.J., Reeh, P., Brownlee, M., Nawroth, P.P. and Bierhaus, A. (2009) Loss of glyoxalase-1 promotes hyperalgesia in early diabetic neuropathy. Diabetologia 52, 1146.
  • Rabbani, N., Chittari, M.V., Zehnder, D., Ceriello, A. and Thornalley, P.J. (2009) High dose metformin therapy reduces glycation and oxidative damage to apolipoprotein B100 and may decelerate atherosclerosis in patients with type 2 diabetes. Diabetologia 52, 1293.
  • Riaz, S., Alam, S.S., Rabbani, N., Thornalley, P.J. and Akhtar, W. (2009) Study of protein biomarker for diabetes type 2 and role of thiamine on their levels. Journal of Physiological Sciences 59, Suppl. 1, 506-506.

  • 2010

  • Karachalias, N., Babaei-Jadidi, R., Rabbani, N. and Thornalley, P.J. (2010) Prevention of decline in glycaemic control in streptozotocin-induced diabetic rats by thiamine but not by Benfotiamine. Diabetic Med. 27, Suppl 1, 74.
  • Ahmed, U., Rabbani, N., Filer, A., Watts, R., Raza, K., and Thornalley, P. (2010) Changes in Advanced Glycation Endproducts in Synovial Fluid in Early Resolving Arthritis and Early and Established Rheumatoid Arthritis. Rheumatology 49, I161

  • 2011

  • Godfrey, L., Thornalley, P.J. and Rabbani, N. (2011) Mimicking the pro-atherogenic phenotype of diabetic dyslipidaemia – glycation by methylglyoxal decreases particle size of HDL2. Diabetic Med. 28, Suppl. 1, 63
  • Rabbani, N., Godfrey, L. and Thornalley, P.J. (2011) Atherogenic transformation of LDL by glycation with methylglyoxal – reduction of particle size and increase binding to the aorta in vivo. Diabetic Med. 28 (Suppl. 1), 63
  • Ahmed, U., Rabbani, N., Costa, M., Watts, R. and Thornalley, P.J. (2011) Increasing concentrations of proteolytic debris of glycated and oxidised proteins in patients with increasing severity of osteoarthritis. Journal of Bone & Joint Surgery 93-B, Supp 1, 70
  • Zhang, F., Larkin, J., Godfrey, L., Rabbani, N. and Thornalley, P.J. (2011) Intensive insulin therapy attenuates renal thiamine mishandling in streptozotocin-induced diabetic rats. Diabetic Med. 28 (Suppl. 1), 63 – 64
  • Ajjan, R.A., Gamlen, T., Standeven, K.F., Mughal, S., Hess, K., Phoenix, F, Anwar, M.M., Rabbani, N., Thornalley, P.J., Philippou, H. and Grant, P.J. (2011) Fructosamine-modified plasminogen in diabetes reversibly inhibits fibrinolysis by reducing plasminogen-fibrin interactions and altering plasmin specific activity. Diabetes 28 (Suppl. 1), A144
  • Rabbani, N., Godfrey, L., Xue, M. and Thornalley, P.J. (2011) Conversion of low density lipoprotein to the small, dense pro-atherogenic form by glycation with methylglyoxal. Diabetes 28 (Suppl. 1), A157
  • Larkin, J.R., Rabbani, N., Zehnder, D. and Thornalley, D.J. (2011) Down regulation of thiamine transporter expression in human tubular epithelial cells in vitro and increased thiamine clearance in diabetes. Diabetes 28 (Suppl. 1), A1
  • Jerums, G, Panagiotopoulos, S., MacIsaac, R.J., Yue, D.K., Fulcher, G.R., Roberts, M., Larkin, J.R., Adaikalakoteswari, A., Rabbani, N. and Thornalley, P.J. (2011) Circulating markers of protein glycation, oxidation and nitration in type 2 diabetes and effect of decline in renal function. Diabetes 28 (Suppl. 1), A166
  • Ahmed, U., Costa, M., Watts, R., Thornalley, P.J., and Rabbani, N. (2011) Increased citrullinated protein in synovial fluid and serum of early and advanced osteoarthritis. BORS, in press
  • Ahmed, U., Filer, A., Raza, K., Thornalley, P.J., and Rabbani, N. (2011) Measurement of citrullinated protein in early rheumatoid arthritis and non-specific synovitis by liquid chromatography-tandem mass spectrometry. BORS, in press
  • Rabbani, N., Adaikalakoteswari, A., Rossing, K., Rossing, P., Parving, H.-H. and Thornalley, P.J. (2011) Glycosylation gap is influenced by Irbesartan treatment in patients with type 2 diabetes and microalbuminuria. Diabetologia 54, Suppl. 1, S444
  • Larkin, J.R., Rabbani, N., Zehnder D., Thornalley, P.J. (2011) Down regulation of thiamine transporter expression in human tubular epithelial cells by high glucose concentration in vitro and increased thiamine clearance in diabetes. www.britishrenal.org/Abstracts/
  • Rabbani, N. and Thornalley, P.J. (2011) The pro-atherogenic phenotype in ageing – lipoprotein B100 and A1 leading the dance into decline of vascular health by oxidative and non-oxidative mechanisms. Rejuvenation Res. http://www.sens.org/node/2139
  • Xue, M., Rabbani, N. and Thornalley, P.J. (2011) Decline of the nuclear factor E2-related factor 2 (nrf2) and antistress gene response in ageing and strategies to prevent it for healthy ageing. Rejuvenation Res. http://www.sens.org/node/2140
  • Thornalley, P.J. and Rabbani, N. (2011) Increased damage to proteins in ageing – wear and tear potentially avoidable by extending preventive maintenance of life’s essential machinery. Rejuvenation Res. http://www.sens.org/node/2138
  • Thornalley, P.J. and Rabbani, N. (2011) Glycation by methylglyoxal in physiological systems – the damage caused and strategies to prevent it. Amino Acids 41 (Suppl 1), S11
  • Rabbani, N. and Thornalley, P.J. (2011) Atherogenic transformation of LDL and impaired function of HDL by glycation. Amino Acids 41 (Suppl 1), S8
  • Thornalley, P.J., Xue, M. and Rabbani, N. (2011) Role of nrf2 and the antistress gene response in countering oxidative stress in diabetes mellitus. Clinical Chemistry And Laboratory Medicine 49, S52-S52
  • Lopez-Clavijo, A.F., Rabbani, N., Thornalley, P.J. and O’Connor, P. (2011) Binding site identification of glyoxal in peptides by ECD and CAD using FT-ICR-MS. http://www.bmss.org.uk/Docs/BMSS%20Meeting%20-%20Posters%205.8.11.pdf

  • 2012

  • Xue, M., Momiji, H., Rabbani, N., Barker, G., Rand, D.A. and Thornalley, P.J. (2012) Control of ARE-linked gene expression by cytoplasm-nucleus translocational oscillations of Nrf2. Free Radical Biology and Medicine 53, Supp 1, S37.
  • Xue, M., Momiji, H., Rabbani, N., Barker, G., Rand, D.A. and Thornalley, P.J. (2012) Multi-tiered protective response of Nrf2 transactivational activity in endothelial cells in vitro. Free Radical Biology and Medicine 53, Supp 1, S233.
  • Xue, M., Momiji, H., Rabbani, N., Barker, G., Rand, D.A. and Thornalley, P.J. (2012) Effect of Nrf2 activators on protein oxidative damage in human endothelial cells in vitro. Free Radical Biology and Medicine 53, Supp 1, S100.
  • Hariton, F., Xue, M., Rabbani, N. and Thornalley, P.J. (2012) Protective response of Nrf2 transactivational activity in MRC-5 fibroblasts in vitro. Free Radical Biology and Medicine 53, Supp 1, S80.
  • Shaheen, F., Wilkinson, D., Rabbani, N. and Thornalley, P.J. (2012) A new sensitive liquid chromatography-tandem mass spectrometry technique to measure 3-nitrotyrosine. Free Radical Biology and Medicine 53, Supp 1, S188.
  • Ahmed, U., Raza, K., Watts, R., Thornalley, P.J. and Rabbani, N. (2012) Oxidative biomarkers increase in patients with increasing severity of rheumatoid arthritis. Free Radical Biology and Medicine 53, Supp 1, S165-S166.
  • Ahmed, U., M.L., Watts, R., Thornalley, P.J. and Rabbani, N. (2012) Oxidative biomarkers increase in patients with increasing severity of osteoarthritis. Free Radical Biology and Medicine 53, Supp 1, S168-S169.

  • 2013

  • Zhang, F., Evans, N.D., Larkin, J.R., Godfrey, L., Yamada-Fowler, N., Chappell, M.J., Rabbani, N. and Thornalley, P.J. (2013) Pharmacokinetics of thiamine in streptozotocin-induced diabetic rats reveals thiamine mishandling in the kidney, retina and peripheral nerve exposing these tissues to increased risk of thiamine deficiency. Diabetic Medicine 30, S1, 67.
  • Masania, J., Thornalley, P.J. and Rabbani,N. (2013) reading the patterns of endogenous damage to the proteins, Annals of Nutrition and Metabolism, 63, 9.
  • Masania, J., Rabbani, N, Klaus, S., Thornalley, P.J. Ost, M. and Keipert, S. (2013) Decreased methylglyoxal-modified protein damage in the HSA-UCP1 mouse model of healthy ageing. Biochem. Soc. Trans. Link
  • Anwar, A., Shaheen, F., Tym, A.E., Masania, J., Rabbani, N. and Thornalley, P.J. (2013) Stable isotopic dilution analysis of AGEs and amino acids metabolome by liquid chromatography-tandem mass spectrometry. Biochem. Soc. Trans. Link
  • Tym, A.E., Jin, T., Rabbani, N., Rossmeisl, M., Kopecky, J., Squires, P. and Thornalley, P.J. (2013) Dicarbonyl stress and beta-cell dysfunction. Biochem. Soc. Trans. Link
  • Ahmed, U., Anwar, A., Costa, M., Watts, R., Thornalley, P.J. and Rabbani, N. (2013) Methylglyoxal and glyoxal derived protein damage markers in diagnosis and progression of osteoarthritis. Biochem. Soc. Trans. Link
  • Shaheen, F., Shymygol, A., Rabbani, N. and Thornalley, P.J. (2013) A fluorogenic assay for methylglyoxal. Biochem. Soc. Trans. Link
  • Rabbani, N., Godfrey L., Yamada-Fowler, N., Smith, J. and Thornalley, P.J. (2013) Methylglyoxal modification is a major factor linked to decreased plasma concentration and functionality of HDL. Biochem. Soc. Trans. Link
  • Shafie, A., Xue, X., Rabbani, N. and Thornalley, P.J. (2013) Difficulties in generating a Glo1 mutant mouse. Biochem. Soc. Trans. Link
  • Waris, S., Winklhofer-Roob, B.M., Roob, J.M., Fuchs, S., Sourij, H., Rabbani, N. and Thornalley, P.J. (2013) Increased dicarbonyl glycation and oxidation adducts of deoxyguanosine in plasma and urine of patients with type 2 diabetes and link to diabetic nephropathy. Biochem. Soc. Trans. Link
  • Ashour, A.A., Thornalley, P.J. and Rabbani, N. (2013) Dicarbonyl stress and the glyoxalase system in periodontal ligament fibroblasts in vitro. Biochem. Soc. Trans. Link
  • Hariton, F.A.G., Xue, M., Rabbani, N. and Thornalley, P.J. (2013) Dicarbonyl stress and the glyoxalase system in fibroblast senescence in vitro. Biochem. Soc. Trans. Link
  • Arai, M., Rabbani, N., Itokawa, M. and Thornalley, P.J. (2013) Glyoxalase activity and dicarbonyl stress in human cell lines of neurological origin. Biochem. Soc. Trans. Link
  • Irshad, Z., Thornalley, P.J. and Rabbani, N. (2013) Disturbance of the glyoxalase system in human vascular endothelial cells by high glucose in vitro. Biochem. Soc. Trans. Link
  • Shaheen, F., Rabbani, N. and Thornalley, P.J. (2013) Glyoxalase 1 copy number variation and its effect on dicarbonyl metabolism. Biochem. Soc. Trans. Link
  • Walley, P.G., Rabbani, N. and Thornalley, P.J. (2013) Methylglyoxal concentration in cotyledons and mature leaves of broccoli (Brassica oleracea L var. italica). Biochem. Soc. Trans. Link

  • 2014

  • Ashour, A., Thornalley, P.J. and Rabbani, N. (2014) Decrease glyoxalase 1 activity increases dicarbonyl stress in periodontal ligament fibroblasts in model hyperglycaemia. Diabetes 63, Suppl. 1, A492.
  • Tym, A., Jin, T., Rossmeisl, M., Kopecky, J., Squires, P., Rabbani, N. and Thornalley, P.J. (2014) Increased pancreatic methylglyoxal in insulin resistance and beta cell detachment from the extracellular matrix. Diabetes 63, Suppl. 1, A553 – A554.
  • Rabbani, N., Godfrey, L., Yamada-Fowler, N., Smith, J. and Thornalley, P.J. (2014) Methylglyoxal derived AGEs increase in HDL isolated from patients with diabetes and increased insulin resistance. Diabetes 63, Suppl. 1, A111
  • Irshad, Z., Xue, M., Thornalley, P.J. and Rabbani, N. (2014) Disturbance of the glyoxalase system in human vascular endothelial cells by high glucose in vitro and reversal by trans-resveratrol. Diabetes 63, Suppl. 1, A9
  • Shafie, A., Xue, M., Thornalley, P.J. and Rabbani, N. (2014) Evaluation of a glyoxalase 1 mutant mouse. Diabetologia 57, Suppl. 1, S528.
  • Rabbani, N., Godfrey, L., Yamada-Fowler, N., Smith, J. and Thornalley, P.J. (2014) One-compartment kinetic model predicts dicarbonyl modification influence half-life and functionality of HDL in high risk CVD group. Diabetologia 57, S529.
  • Thornalley, P.J., Irshad, Z., Xue, M. and Rabbani, N. (2014) Metabolic modelling of methylglyoxal formation, metabolism and AGE formation in vascular endothelial cells in model hyperglycemia in vitro. Diabetologia 57, Suppl. 1, S34 – S35.
  • van Schothorst, E.M., Duivenvoorde, L., Derous, D., van der Stelt, I., Masania, J., Rabbani, N., Thornalley, P.J., and Keijer, J. (2014) Oxygen restriction as challenge test reveals early diet-induced health effects. Diabetologia 57, Suppl. 1, S232.
  • Arai, M., Miyashita, M., Kobori, A., Toriumi, K., Horiuchi, Y., Rabbani, N., Thornalley, P. and Itokawa, M. (2014) Idiopathic carbonyl stress in a subpopulation of schizophrenia. Early Intervention in Psychiatry 8, 36 – 36.
  • Arai, M., Miyashita, M., Kobori, A., Toriumi, K., Horiuchi, Y., Rabbani, N., Thornalley, P.J. and Itokawa, M. (2014) Research on dicarbonyl accumulation and AGEs formation in schizophrenia. Early Intervention in Psychiatry 8, 98 – 98.

  • 2015

  • Rabbani, N. and Thornalley, P.J. (2015) Methylglyoxal modification of low density lipoprotein – a novel route to the pro-atherogenic, small dense LDL with increased arterial proteoglycan binding and aortal retention. Atherosclerosis 241, e56.
  • Xue, M., Momiji, H., Rabbani, R., Barker, G., Shmygol, A., Bretschneider, T., Rand, D.A.and Thornalley, P.J. (2015) Antioxidant response element cytoprotective response in aortic endothelial cells coordinated by transcription factor Nrf2 is regulated through frequency-modulated translocational oscillations. Atherosclerosis 241, e2.
  • Rabbani, N. and Thornalley, P.J. (2015) Arginine-directed glycation by methylglyoxal is a factor decreasing HDL plasma concentration and functionality in vivo. Atherosclerosis 241, e33.
  • Maldonado, E.M., Rabbani, N., Thornalley, P.J., Wang, H., Miller, M., Dillon, J.F. and Moore, J.B. (2015) Examination of methylglyoxal levels in an in vitro model of steatosis and serum from patients with non-alcoholic fatty liver disease. Proceedings of the Nutrition Society 74, E1.

  • 2016

  • Rabbani, N. and Thornalley, P.J. (2016) Physiological glycation by methylglyoxal, glyoxalase 1 and developments in disease mechanisms and clinical therapeutics. The FEBS Journal 283 (Suppl. 1) 12–54.
  • Rabbani, N., Xue, M., Weickert, M.O., Qureshi, S., Kandala, N.-B., Anwar, A., Waldron, M., Shafie, A. and Thornalley, P.J. (2016) Discrimination between advanced glycation endproducts of endogenous and dietary origin in overweight and obese non-diabetic subjects. Diabetologia. 59, S535 – S536.
  • Shafie, A., Xue, M., Thornalley, P.J. and Rabbani, N. (2016) Dicarbonyl stress induces glyoxalase 1 copy number increase in mouse embryonic stem cells in vitro and escapes mutation lethality in gene trapping. Diabetologia 59, S525 – S526.
  • Xue, M., Weickert, M.O., Qureshi, Q., Kandala, N.-B., Anwar, A., Waldron, M., Shafie, A., Rabbani, N. and Thornalley, P.J. (2016) An inducer of glyoxalase 1 down regulates inflammatory gene expression in overweight and obese non-diabetic subjects. Diabetologia 59, S300.
  • Thornalley, P.J., Xue, M., Weickert, M.O., Qureshi, Q., Kandala, N.-B., Anwar, A., Waldron, M., Shafie, A. and Rabbani, N. (2016) An inducer of glyoxalase 1 improves insulin resistance and glycaemic control in overweight and obese non-diabetic subjects. Diabetologia 59, S141 – S142.
  • Ashour, A., Thornalley, P.J., and Rabbani, N. (2016) A glyoxalase 1 inducer protects human periodontal ligament fibroblasts from dicarbonyl stress and dysfunction in model hyperglycaemia in vitro. Diabetologia 59, S522.

  • 2017

  • Xue, M., Weickert, M.O., Rabbani, N. and Thornalley, P.J. (2017) Glyoxalase-1 inducer treatment in obesity correlates with improved glycemic control, vascular inflammation, and dyslipidemia. Diabetes 66 (Supplement 1), A334.
  • Rabbani, N., Xue, M., Weickert, M.O. and Thornalley, P.J. (2017) Endogenous and dietary contributions to advanced glycation endproducts. Diabetes. 66 (Supplement 1), A562
  • Ashour, A., Thornalley, P.J., and Rabbani, N. (2017) Impaired adhesion of human periodontal ligament fibroblast to collagen-I in model hyperglycaemia in vitro is corrected by Glo1inducer. Diabetologia 60 (Suppl. 1), S558.
  • Thornalley, P.J., Ashour, A., Irshad, Z., and Rabbani, N. (2017) Disturbance of the cytosolic proteome in human aortal endothelial cells in high glucose concentration in vitro Diabetologia 60 (Suppl. 1), S539
  • Rabbani, N., Ashour, A., Pasha, S., Shafie, A. and Thornalley, P.J. (2017) Glyoxalase-1 inducer corrects down regulated cytosolic proteome in periodontal ligament fibroblasts in model hyperglycaemia. Diabetologia 60 (Suppl. 1), S558 – S559.
  • Ahmed, U., Thornalley, P.J., and Rabbani, N. (2017) Two-step algorithm for early diagnosis of osteoarthritis based on plasma damaged amino acids provides simple and low cost screening test. Ann Rheumatic Dis. 76, Suppl. 2, 1025-1025
  • Ahmed, U., Thornalley, P.J., and Rabbani, N. (2017) Increased protein glycation, oxidation and nitration with increasing severity of rheumatoid arthritis in a cross-sectional study assessed by robust stable isotopic dilution analysis quantitation. Rheumatology 56, suppl. 2, ii125.
  • Ahmed, U., Thornalley, P.J., and Rabbani, N. (2017) Protein oxidation, nitration and glycation free adducts biomarkers for early-stage diagnosis and typing of arthritis. Rheumatology 56, suppl. 2, 163-164.

  • 2018

  • Ahmed, U., Lambert, C., Legrand, C., Anwar, A., Rajpoot, K., Pasha, S., Davidson, R., Clark, I., Thornalley, P., Rabbani, N. and Henrotin, Y. (2018) Glucosepane: a new biomarker of the severity of osteoarthritis. Osteoarthritis & Cartilage 26, Suppl. 1, S181.
  • Thornalley, P.J., Irshad, Z., Xue, M., Ashour, A. and Rabbani, N. (2018) Increased hexokinase-2-catalysed entry of glucose into glycolysis – key driver of metabolic dysfunction in endothelial cells in hyperglycemia. Diabetologia 61, Suppl 1, S68.
  • Rabbani, N. Irshad, Z., Xue, M., Ashour, A. and Thornalley, P.J. (2018) Methylglyoxal driven endothelial dysfunction in hyperglycemia targets protein folding, protein synthesis, glycolysis and gluconeogenesis pathways. Diabetologia 61, Suppl 1, S68.
  • Xue, M., Irshad, Z., Ashour, A. and Thornalley, P.J. and Rabbani, N. (2018) Increased methylglyoxal protein modification in hyperglycemia induces an inflammatory phenotype in endothelial cells in hyperglycemia by activation of the unfolded protein response. Diabetologia 61, Suppl 1, S546.
  • Abbas, H., Xue, M., Rabbani, N. and Thornalley, P.J. (2018) Glyoxalase 1 overexpression associated multidrug resistance in cancer chemotherapy. Brit. J Cancer 19, 47.

  • 2019

  • Thornalley, P.J., Xue, M., Ashour, M. and Rabbani, N. (2019) Combination of trans-resveratrol and hesperetin corrects unscheduled increased glucose metabolism driving endothelial cell dysfunction in hyperglycemia in vitro. Diabetes 68, suppl. 1, 485
  • Ashour, M., Rabbani, N. Thornalley, P.J. and Xue, M. (2019) Combination Of Trans-Resveratrol And Hesperetin Corrects Unscheduled Increased Glucose Metabolism Driving Dysfunction Of Human Periodontal Ligament Fibroblasts In Hyperglycemia In Vitro. Diabetes, 68, Suppl. 1, 479.

  • 2020

  • Al-Motawa, M.S., Rabbani, N. and Thornalley, P.J. (2020) Use of protein informatics to assess how mutations of glucokinase affect enzymatic function. Diabetologia 63, Suppl. 1, S153.

  • 2021

  • Xue, M., Weickert, M.O., Rabbani, N. and Thornalley, P.J. (2021) Reversal of insulin resistance by resveratrol and hesperetin combination in overweight and obese subjects correlates with decrease in expression of thioredoxin interacting protein. Diabetes 70, Suppl. 1, 338-OR.
  • Rabbani, N., de la Fuente, A. and Thornalley, P.J. (2021) Risk prediction of early decline in renal function in diabetic kidney disease with algorithm including fractional excretion of glycated amino acids. Diabetes 70, Suppl. 1, 186-OR.
  • Thornalley, P.J., Xue, M. and Rabbani, N. (2021) Dynamics of hexokinase-2 linked glycolytic overload mediating endothelial cell dysfunction in high glucose concentration in vitro. Diabetologia 64, Suppl. 1, 331.
  • Abbas, H., Xue, M., Rabbani, N. and Thornalley, P.J. (2021) Glyoxalase 1 – a multidrug resistance factor in cancer chemotherapy. IMARS Highlights 16 (6), 96.
  • de la Fuente, A., Rabbani, N. and Thornalley, P.J. (2021) Risk prediction of early decline in renal function in diabetic kidney disease with an algorithm including fractional excretion of glycated amino acids. IMARS Highlights 16 (6), 99.
  • Xue, M., Rabbani, N. and Thornalley, P.J. (2021) Dicarbonyl stress increases expression of thioredoxin interacting protein and CHOP linked to the NLRP3 Inflammasome in human aortal endothelial cell in vitro. IMARS Highlights 16 (6), 101.
  • Al-ali, A.S., Qidwai, U., Fetais, N., Thornalley, P.J. and Rabbani, N. (2021) ANFIS classifier for early diagnosis of autistic spectrum disorder based on plasma amino acid metabolome biomarkers. IMARS Highlights 16 (6), 104.
  • Jabbar, R., Said, A.B., Fetais, N., Rabbani, N. and Thornalley, P.J. (2021) Machine-learning-based prediction models for early-stage diagnosis of knee osteoarthritis‏ using protein oxidation, nitration and glycation biomarkers. IMARS Highlights 16 (6), 105.
  • Rabbani, N., Xue, M., Weickert, M.O. and Thornalley, P.J. (2021) Urinary glucosepane as a marker of glycemic control in non-diabetic subjects – insight from the HATFF study. IMARS Highlights 16 (6), 110.
  • Elbashir, I., Al-Saei, A.N.J.M.A-S., Thornalley, P.J. and Rabbani, N. (2021) Evaluation of antiviral activity of Manuka honey against SARS-CoV-2. IMARS Highlights 16 (6), 122.
  • Al-Motawa, M., Rabbani,N. and Thornalley, P.J. (2021) Genetics of glycation – glycated hemoglobin, GLO1 single nucleotide polymorphisms and copy number variation. IMARS Highlights 16 (6), 35.
  • Alhujaily, M., Xue, M., de la Fuente, A., Rabbani, N., and Thornalley, P.J. (2021) The spliceosome is a target for glycation in methylglyoxal-induced apoptosis and is shielded by glyoxalase 1 in multidrug resistance-linked cancer chemotherapy. IMARS Highlights 16 (6), 57.
  • Xue, M, Rabbani, N. and Thornalley, P.J. (2021) Anti-inflammatory activity of glyoxalase-1 inducer, trans-resveratrol and hesperetin, in human small airway epithelial cell primary cultures support application for prevention of COVID-19. IMARS Highlights 16 (6), 51.
  • Alhujaily,M., Abbas,H., Xue,M., de la Fuente, A., Rabbani,N. and Thornalley, P.J. (2021) Methylglyoxal is a common contributor and glyoxalase 1 a negative survival factor in cancer chemotherapy, respectively targeting and shielding the spliceosome. Clin Cancer Invest J

  • 2022

  • Xue, M., Rabbani, N. and Thornalley, P.J. (2022) Anti-inflammatory activity of glyoxalase-1 inducer supports further evaluation for prevention of COVID-19. Diabetes Res. Clin. Pract. 186, Suppl. 1, 109325.
  • AlKhatib, H.A.M., Elbashir, I., Yassine, H., Thornalley, P.J. and Rabbani, N. (2021) Antiviral activity of glucose-derived reactive metabolite, methylglyoxal against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). J Emerg Med Trauma & Acute Care 2022, 8.
  • Xue, M., Al-Motawa, M., Rabbani, N. and Thornalley, P.J. (2022) Hexokinase-2 linked glycolytic overload – key initiating driver of the development of diabetic vascular complications. Diabetes Res. Clin. Pract. 186, Suppl. 1, 109255.
  • Al-Saei, A.N.J.M., El Dine, W.N., Yaseen Al-ali, A.S., Ahmed Qidwai, U., Fetais, N., Thornalley, P.J., Al-Shammari, A.R. and Rabbani, N. (2022) Validation of diagnostic algorithm of a simple blood test for autism. Qatar University Health.
  • Xue, M., Rabbani, N. and Thornalley, P.J. (2022) Increase of hexokinase-2 protein without increase of other glycolytic enzymes in myotubes with high glucose concentration supports the hypothesis of hexokinase-2-linked unscheduled glycolysis as a driver of insulin resistance. Diabetes 71, Supp. 1, 206-LB.
  • Xue, M., Rabbani, N. and Thornalley, P.J. (2022) Hexokinase-2 linked scheduled glycolysis as a driver of insulin resistance linked dysglycemia – evidence in the murine C2C12 myotube model in vitro. Diabetologia 65 (Suppl 1), S230.
  • Thornalley, P.J., Xue, M. and Rabbani, N. (2022) High glucose concentration-induced dicarbonyl stress in human aortal endothelial cells activates the unfolded protein response and NLRP3 Inflammasome. Diabetologia 65 (Suppl 1), S425.
  • Rabbani, N., Panagiotopoulos, S., MacIsaac, R.J., Yue, D.K., Fulcher, G.R., Roberts, M.A., Ekinci, E. and Thornalley, P.J. (2022) Advanced glycation endproducts in chronic kidney disease in subjects with and without diabetes – AGEs highly responsive to renal function decline and diabetes. Diabetologia 65 (Suppl 1), S392.

  • 2023

  • Wijten, P., Alsaei, A., Rabbani, N., & Thornalley, P.J. (2023) Establishing reference intervals for plasma amino acids and trace level glycated amino acids of healthy subjects in Qatar. J Diabetes Endocrine Practice, 6(2), 78.

  • 2024

  • Xue, M., Rabbani, N. and Thornalley, P.J. (2024) Dicarbonyl Stress Is a Dominant Activator of the Unfolded Protein Response in Hyperglycemia. J Diabetes Endocrine Practice 6 (2), 79. Xue, M., Rabbani, N. and Thornalley, P.J. (2023) Activation of three pathways of the unfolded protein response in endothelial cells by methylglyoxal in hyperglycemia. Diabetes Res. Clin. Pract. 187, Suppl. 1, in press.
  • Rabbani, N., & Thornalley, P.J. (2024) Hyperglycemia-induced cell damage by circumvention of hexokinase saturation at sites of diabetic vascular complications. Diabetes Res. Clin. Pract. 187, Suppl. 1, in press.