Peer-reviewed articles in journals and chapters in books

Move on Year Wise 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 2007 | 2008 | 2009 | 2010 | 2011 | 2012 | 2013 | 2014 | 2015 | 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | 2023 | 2024

  • 2000

  • Thornalley, P.J., Argirova, M., Argirov, O.K., Ahmed, N., Mann, V.M. and Dawnay, A. (2000) Mass spectrometric monitoring of albumin in uraemia. Kidney Internat. 58, 2228-2234.

  • 2002

  • Ahmed, N., Argirov, O.K., Minhas, H.S., Cordeiro, C. and Thornalley, P.J. (2002) Assay of advanced glycation endproducts (AGEs): surveying AGEs by chromatographic assay with derivatisation by aminoquinolyl-N-hydroxysuccimidyl-carbamate and application to Ne-carboxymethyl-lysine- and Ne-(1-carboxyethyl)lysine-modified albumin. Biochem. J. 364, 1 – 14.
  • Ahmed, N. and Thornalley, P.J. (2002) Chromatographic assay of glycation adducts in human serum albumin glycated in vitro by derivatisation with aminoquinolyl-N-hydroxysuccimidyl-carbamate and intrinsic fluorescence. Biochem. J. 364, 15 – 24.

  • 2003

  • Babaei-Jadidi, R., Karachalias, N., Battah, S., Ahmed, N.M. and Thornalley, P.J. (2003) Prevention of incipient diabetic nephropathy by high dose thiamine and Benfotiamine. Diabetes 52, 2110-2120.
  • Thornalley, P.J., Battah, S., Ahmed, N., Karachalias, N., Agalou, S., Babaei-Jadidi, R. and Dawnay, A. (2003) Quantitative screening of advanced glycation endproducts in cellular and extracellular proteins by tandem mass spectrometry. Biochem. J. 375, 581-592.
  • Ahmed, N., Battah, S., Karachalias, N., Babaei-Jadidi, R., Horányi, M., Baróti, M., Hollan, S., and Thornalley, P.J. (2003) Increased formation of methylglyoxal and protein glycation, oxidation and nitrosation in triosephosphate isomerase deficiency. Biochim. Biophys. Acta Mechanisms of disease 1639, 121-132.
  • Ahmed, N., Thornalley, P.J., Dawczynski, J., Franke, S., Strobel, J. and Stein, G. (2003) Methylglyoxal-derived hydroimidazolone advanced glycation endproducts of human lens proteins. Invest. Ophthamol. Vis. Sci. 44, 5287-5202.

  • 2004

  • Ahmed, N., Thornalley, P.J., Lüthen, R., Häussinger, D., Sebekova, K., Schinzel, R., Voelker, W. and Heidland, A. (2004) Processing of protein glycation, oxidation and nitrosation adducts in the liver and the effect of cirrhosis. J. Hepatology 41, 913-919.
  • Jono, T., Nagai, R., Lin, X., Ahmed, N., Thornalley, P.J., Takeya, M., Horiuchi, S. (2004) Nε-(Carboxymethyl)lysine and 3-DG-imidazolone are major AGE structures in protein modification by 3-deoxyglucosone. J. Biochem. 136, 351-358.
  • Babaei-Jadidi, R., Karachalias, N., Kupich, C., Ahmed, N. and Thornalley, P.J. (2004) High dose thiamine therapy counters dyslipidaemia in diabetes. Diabetologia 47, 2235 – 2246.

  • 2005

  • Ahmed, N., Ahmed, U., Hager, K., Fleischer, G., Münch, G. and Thornalley, P.J. (2005) Protein glycation, oxidation and nitration marker residues and free adducts of cerebrospinal fluid in Alzheimer’s disease and link to cognitive impairment. J. Neurochem. 92, 255–263.
  • Ahmed, N., Dobler, D., Dean, M.and Thornalley, P.J. (2005) Peptide mapping identifies hotspot site of modification in human serum albumin by methylglyoxal involved in ligand binding and esterase activity. J. Biol. Chem. 280, 5724-5732.
  • Agalou, A., Ahmed, N., Babaei-Jadidi, R., Dawnay, A. and Thornalley, P.J. (2005) Profound mishandling of protein glycation degradation products in uremia and dialysis. J. Am. Soc. Nephrol. 16, 1471 – 1485.
  • Berlanga, J., Cibrian, D., Guillén, I., Freyre, F., Alba, J.S., Merino, N., Aldama, A., Quintela, A.M., Triana, M.E., Ajameich, H., Lopez, P., Ahmed, N. and Thornalley, P.J. (2005) Methylglyoxal administration induces diabetes-like microvascular changes and perturbs the healing process of skin wounds. Clin. Sci. 109, 83-95.
  • Ahmed, N., Mirshekar-Syahkal, B., Kennish, L., Karachalias, N., Babaei-Jadidi, R. and Thornalley, P.J. (2005) Assay of advanced glycation endproducts in selected beverages and food by liquid chromatography with tandem mass spectrometric detection. Molec. Nutrit. Food Res. 47, 691-699.
  • Babaei-Jadidi, R., Karachalias, N., Kupich, C., Ahmed, N. and Thornalley, P.J. (2005) High dose thiamine therapy counters dyslipidemia and advanced glycation of plasma protein in streptozotocin-induced diabetic rats. Ann. N.Y. Acad. Sci. 1043, 777 – 783.
  • Ahmed, N. and Thornalley, P.J. (2005) Peptide mapping of human serum albumin modified minimally by methylglyoxal in vitro and in vivo. Ann. N.Y. Acad. Sci. 1043, 260 – 266.
  • Agalou, S, Ahmed, N, Thornalley, P.J. and Dawnay, A. (2005) Removal of free advanced glycation endproducts by haemodialysis. Ann. N.Y. Acad. Sci. 1043, 734 – 739.
  • Ahmed, N., Thornalley, P.J., Lüthen, R., Häussinger, D.,Sebekova, K., Schinzel, R., Voelker, W. and Heidland, A. (2005) Increased protein glycation in cirrhosis. Ann. N.Y. Acad. Sci. 1043, 718 – 724.
  • Ahmed, N., Babaei-Jadidi, R., Howell, S.K., Beisswenger, P.J.and Thornalley, P.J. (2005) Degradation products of proteins damaged by glycation, oxidation and nitration in clinical type 1 diabetes. Diabetologia 48, 1590 – 1603.

  • 2006

  • Dobler, D., Ahmed, N., Song, L., Eboigbodin, K.E. and Thornalley, P.J. (2006) Increased dicarbonyl metabolism in endothelial cells in hyperglycemia induces anoikis and impairs angiogenesis by RGD and GFOGER motif modification. Diabetes 55, 1961-1969.
  • Dobler, D., Ahmed, N., Thornalley, P.J. (2006) Peptide mapping of glycation sites of human serum albumin in vitro and in vivo by LC-MS/MS analysis. J. Chromatogr. B. 842, 115 – 126.
  • Ahmed, N., Dobler, D., Dean, M. and Thornalley, P.J. (2006) Urinary protein glycation, oxidation and nitration adducts as biomarkers of diabetic nephropathy. Diabetes Care 28, 2465 – 2470.
  • Dobler, D., Ahmed, N. and Thornalley, P.J. (2006) Quantitation of glycation adducts by stable isotopic dilution analysis LC-MS/MS with novel mimetic internal standards. J. Proteome Res. 5, 689 – 699.
  • Babaei-Jadidi, R., Karachalias, N., Ahmed, N., Battah, S., Thornalley, P.J. (2006) Prevention of incipient nephropathy by high dose thiamine and benfotiamine in diabetic rats is associated with improved markers of renal function, DNA damage and reduced expression of the receptor for advanced glycation endproducts (RAGE). Diabetes 55, 1505 – 1513.
  • Thornalley, P.J., Jahan, I. and Ng, R. (2006) Suppression of the receptor for advanced glycation endproducts (RAGE) in human leukemia cells by methylglyoxal is linked to apoptosis and dicarbonyl stress. Biochem. Soc. Trans. 34, 766 – 770.
  • Ahmed, N., Dobler, D. and Thornalley, P.J. (2006) Peptide mapping of glycation sites of human serum albumin in vitro and in vivo by LC-MS/MS analysis. J. Chromatogr. B. 842, 115 – 125.
  • Dobler, D., Ahmed, N. and Thornalley, P.J. (2006) Biotin hydrazide as a probe for detection of plasma protein glycation. Biochem. Soc. Trans. 34, 679 – 682.
  • Ahmed, N., Dobler, D., Dean, M. and Thornalley, P.J. (2006) Biomarkers of protein damage in uremia and dialysis patients – glycated, oxidised and nitrated proteins and amino acids. Nephrol. Dial. Transplant. 21, 149 – 159.

  • 2007

  • Ahmed, N. and Thornalley, P.J. (2007) Advanced glycation endproducts: What is their relevance to diabetic complications? Diabetes, Obesity and Metabolism 9, 233-245.
  • Ahmed, N. and Thornalley, P.J. (2007) Peptide mapping of glycation sites of human serum albumin in vitro and in vivo by LC-MS/MS analysis. J. Chromatogr. B. 842, 115 – 125.
  • Dobler, D., Ahmed, N. and Thornalley, P.J. (2007) Quantitation of glycation adducts by stable isotopic dilution analysis LC-MS/MS with novel mimetic internal standards. J. Proteome Res. 5, 689 – 699.
  • Dobler, D., Ahmed, N. and Thornalley, P.J. (2007) Biotin hydrazide as a probe for detection of plasma protein glycation. Biochem. Soc. Trans. 34, 679 – 682.
  • Thornalley, P.J., Jahan, I. and Ng, R. (2007) Suppression of the receptor for advanced glycation endproducts (RAGE) in human leukemia cells by methylglyoxal is linked to apoptosis and dicarbonyl stress. Biochem. Soc. Trans. 34, 766 – 770.

  • 2008

  • Babaei-Jadidi, R., Karachalias, N., Ahmed, N., Battah, S., Thornalley, P.J. (2008) Prevention of incipient nephropathy by high dose thiamine and benfotiamine in diabetic rats is associated with improved markers of renal function, DNA damage and reduced expression of the receptor for advanced glycation endproducts (RAGE). Diabetes 55, 1505 – 1513.
  • Ahmed, N., Dobler, D. and Thornalley, P.J. (2008) Biomarkers of protein damage in uremia and dialysis patients – glycated, oxidised and nitrated proteins and amino acids. Nephrol. Dial. Transplant. 21, 149 – 159.
  • Dobler, D., Ahmed, N., Thornalley, P.J. (2008) Peptide mapping of glycation sites of human serum albumin in vitro and in vivo by LC-MS/MS analysis. J. Chromatogr. B. 842, 115 – 125.
  • Ahmed, N., Dobler, D., Dean, M. and Thornalley, P.J. (2008) Urinary protein glycation, oxidation and nitration adducts as biomarkers of diabetic nephropathy. Diabetes Care 28, 2465 – 2470.

  • 2009

  • Thornalley, P.J., Jahan, I. and Ng, R. (2009) Suppression of the receptor for advanced glycation endproducts (RAGE) in human leukemia cells by methylglyoxal is linked to apoptosis and dicarbonyl stress. Biochem. Soc. Trans. 34, 766 – 770.
  • Ahmed, N., Dobler, D., Dean, M. and Thornalley, P.J. (2009) Biomarkers of protein damage in uremia and dialysis patients – glycated, oxidised and nitrated proteins and amino acids. Nephrol. Dial. Transplant. 21, 149 – 159.
  • Dobler, D., Ahmed, N., Thornalley, P.J. (2009) Peptide mapping of glycation sites of human serum albumin in vitro and in vivo by LC-MS/MS analysis. J. Chromatogr. B. 842, 115 – 125.
  • Ahmed, N., Dobler, D., Dean, M. and Thornalley, P.J. (2009) Urinary protein glycation, oxidation and nitration adducts as biomarkers of diabetic nephropathy. Diabetes Care 28, 2465 – 2470.

  • 2010

  • Ahmed, N., Dobler, D., Dean, M. and Thornalley, P.J. (2010) Biomarkers of protein damage in uremia and dialysis patients – glycated, oxidised and nitrated proteins and amino acids. Nephrol. Dial. Transplant. 21, 149 – 159.

  • 2011

  • Rabbani, N. and Thornalley, P.J. (2011) Protein damage in diabetes and uremia – identifying hotspots of proteome damage where minimal modification is amplified to marked pathophysiological effect. Free Radical Research 45, 89 – 100.
  • Thornalley, P.J. and Rabbani, N. (2011) Thiamine in diabetic renal disease – dietary insufficiency, renal washout, anti-stress gene response, therapeutic supplements, risk predictor and link to genetic susceptibility. In: ‘Oxidative Stress in Applied Basic Research and Clinical Practice: Renal Disorders (Miyata, T., Eckardt, K.-U. and Nangaku, M. eds), Human Press, 93 – 104.
  • Kurz, A., Rabbani, N., Walter, M., Bonin, M., Thornalley, P.J., Auburger, G. and Gispert, S. (2011) Alpha-synuclein deficiency leads to increased glyoxalase I expression and glycation stress. Cell and Molecular Life Sci. 68, 721 – 733.
  • Rabbani, N. and Thornalley, P.J. (2011) The glyoxalase system – from microbial metabolism, through ageing to human disease and multidrug resistance. Seminars in Cell and Developmental Biology 22, 261.
  • Xue, M., Rabbani, N. and Thornalley, P.J. (2011) Glyoxalase in ageing. Seminars in Cell and Developmental Biology 22, 293 – 301.
  • Rabbani, N. and Thornalley, P.J. (2011) Glyoxalase in tumourigenesis and multidrug resistance. Seminars in Cell and Developmental Biology 22, 318 – 325.
  • Rabbani, N. and Thornalley, P.J. (2011) Glyoxalase in diabetes, obesity and related disorders. Seminars in Cell and Developmental Biology 22, 309 – 317.
  • Rabbani, N. and Thornalley, P.J. (2011) Emerging role of thiamine therapy for prevention and treatment of early stage diabetic nephropathy. Diabetes, Obesity and Metabolism 13, 577 – 583.
  • Rabbani, N., Godfrey, L., Xue, M., Shaheen, F., Geoffrion, M., Milne, R. and Thornalley, P.J. (2011) Glycation of LDL by Methylglyoxal Increases Arterial Atherogenicity. A Possible Contributor to Increased Risk of Cardiovascular Disease in Diabetes. Diabetes 60, 1973-1980.
  • Thornalley, P.J, Xue, M.and Rabbani, N. (2011) Methodologies for in-vitro and in-vivo activity of bioactive compounds. In: Health-Promoting Properties of Fruits and Vegetables (Terry, L. ed.), CABI, Oxford, UK, 180 – 204.
  • Rabbani, N. and Thornalley, P.J. (2011) Methylglyoxal modification of LDL – pro-atherogenicity without oxidation opens new paths to prevention of cardiovascular disease. Clinical Lipidology 6, 631-634.

  • 2012

  • Thornalley, P.J. and Rabbani, N. (2012) Dietary and synthetic activators of the antistress gene response in treatment of renal disease. J. Renal Nutrit. 22, 195-202.
  • Xue, M., Rabbani, N., Momiji, H., Imbasi, P., Anwar, M.M., Kitteringham, N., Parks, B.K., Souma, T., Moriguchi, T., Yamamoto, M. and Thornalley, P.J. (2012) Transcriptional control of glyoxalase 1 by Nrf2 provides a stress responsive defence against dicarbonyl glycation. Biochem. J. 443, 213 – 222.
  • Adaikalakoteswari, A., Rabbani, N., Waspadji, S., Tjokroprawiro, A., Kariadi, H.K.S., Adam, J.M.F. and Thornalley, P.J. (2012) Disturbance of B-vitamin status in patients with type 2 diabetes in Indonesia – link to renal status, glycemic control and vascular inflammation. Diabetes Research & Clinical Practice 95, 415 – 424.
  • Rabbani, N. and Thornalley, P.J. (2012) Amino Acids Glycation Section. Amino Acids 42, 1085–1086
  • Rabbani, N. and Thornalley, P.J. (2012) Glycation research in Amino Acids – a place to call home. Amino Acids 42, 1087–1096.
  • Rabbani, N. and Thornalley, P.J. (2012) Methylglyoxal, glyoxalase 1 and the dicarbonyl proteome. Amino acids 42, 1133-1142.
  • Rabbani, N., Adaikalakoteswari, A., Rossing, K., Rossing, P., Tarnow, L., Parving, H.-H. and Thornalley, P.J. (2012) Effect of Irbesartan treatment on plasma and urinary protein glycation, oxidation and nitration markers in patients with type 2 diabetes and microalbuminuria. Amino Acids 42, 1627-1639
  • Bierhaus, A., Stoyanov, S., Fleming, T., Sauer, S.K., Leffler, A., Babes, A., Kichko, T.I., Neacsu, C., Konrade, I., Pirags, V., Lukic, I.K., Morcos, M., Dehmer, T., Rabbani, N., Thornalley, P.J., Edelstein, D., Nau, C., Forbes, J., Stern, D.M., Cooper, M.E, Humpert, P.M., Brownlee, M., Reeh, P. and Nawroth, P.P. (2012) Metabolic hyperalgesia – a novel concept based on the reactive metabolite methylglyoxal and the sensory neuronal Na+ channel Nav1.8. Nature Medicine 18, 926–933
  • Perkins, B.A., Rabbani, N., Weston, A., Ficociello, L.H., Antonysunil, A., Niewczas, M., Warram, J., Krolewski, A. and Thornalley, P.J. (2012) Plasma levels of advanced glycation endproducts and other markers of protein damage in type 1 diabetes patients with new onset microalbuminuria. PLOS One 7(4): e35655
  • Rabbani, N. and Thornalley, P.J. (2012) Dicarbonyls (Glyoxal, methylglyoxal, and 3-deoxyglucosone).In: Uremic Toxins (Niwa, T., Ed.) Wiley-Blackwell, 177 – 192.
  • Rabbani, N. and Thornalley, P.J. (2012) Advanced glycation end-product (AGE)-modified proteins and peptides.In: Uremic Toxins (Niwa, T., Ed.) Wiley-Blackwell, 293 – 304.

  • 2013

  • Larkin, J.R., Zhang, F., Godfrey, L. Rabbani, N., Zehnder, D. and Thornalley, P.J. (2013) Down regulation of thiamine transporter expression in human kidney proximal tubular epithelial cells in hyperglycemia. PLOSOne 7 (12), e53175
  • Lopez-Clavijo, A.F., Barrow, M.P., Rabbani, N., Thornalley, P.J. and O’Connor, P.B. (2013) Determination of Types and Binding Sites of Advanced Glycation End Products for Substance P. Anal. Chem. 84, 10568 – 10575
  • Klooster, A., Larkin, J.R., Wiersema-Buist, J., Gans, R.O.B., Thornalley, P.J., Navis, G., van Goor, H., Leuvenink, H.G.D. and Bakker, S.J.L. (2013)Are brain and heart tissue prone to the development of thiamine deficiency? Alcohol 47, 215 – 221.
  • Ajjan, R.A., Gamlen, T., Standeven, K.F., Mughal, S., Hess, K., Smith, K.A., Dunn, E.J., Phoenix, F., Anwar, M.M., Rabbani, N., Thornalley, P.J., Philippou, H. and Grant, P.J. (2013) Fructosamine modified plasminogen alters plasminogen-fibrin interactions and the specific activity of plasmin to inhibit fibrinolysis. Blood 122, 134 – 142.
  • Fleming, T.H., Theilen, T.-M., Masania, J., Wunderle, M., Karimi, J., Vittas, S., Bernauer, R., Bierhaus, A., Rabbani, N., Thornalley, P.J., Kroll, J., Tyedmers, J., Nawrotzki, R., Herzig, S., Brownlee, M. and Nawroth, P.P. (2013) Aging-dependent reduction in Glyoxalase-I delays wound healing. Gerontology 59, 427 – 437

  • 2014

  • Thornalley, P.J. and Rabbani, N. (2014) Detection of oxidized and glycated proteins in clinical samples using mass spectrometry – a user’s perspective. Biochim. Biophys.Acta 1840, 818 – 829.
  • Thornalley, P.J. and Rabbani, N. (2014) Commentary: the critical role of methylglyoxal and glyoxalase 1 in diabetic nephropathy. Diabetes 63, 50 – 52
  • Rabbani, N. and Thornalley, P.J. (2014) Glyoxalase Centennial conference: introduction, history of research on the glyoxalase system and future prospects. Biochem. Soc. Trans. 42, 413 – 418.
  • Rabbani, N., Xue, M. and Thornalley, P.J. (2014) Activity, regulation, copy number and function in the glyoxalase system. Biochem. Soc. Trans. 42, 419 – 424.
  • Arai, M., Nihonmatsu-Kikuchi, N., Itokawa, M., Rabbani, N. and Thornalley, P.J. (2014) Measurement of glyoxalase activities. Biochem. Soc. Trans. 42, 491 – 494.
  • Thornalley, P.J. and Rabbani, N. (2014) Assay of methylglyoxal and glyoxal and control of peroxidase interference. Biochem. Soc. Trans. 42, 504 – 510.
  • Shaheen, F., Shmygol, A., Rabbani, N. and Thornalley, P.J. (2014) A fluorogenic assay for methylglyoxal. Biochem. Soc. Trans. 42, 548 – 555.
  • Rabbani, N., Shaheen, F., Anwar, A., Masania, J. and Thornalley, P.J. (2014) Assay of methylglyoxal-derived protein and nucleotide advanced glycation endproducts. Biochem. Soc. Trans. 42, 511 – 517
  • Shafie, A., Xue, M., Thornalley, P.J. and Rabbani, N. (2014) Copy number variation of Glyoxalase 1. Biochem. Soc. Trans. 42, 500 – 503.
  • Xue, M., Rabbani, N. and Thornalley, P.J. (2014) Measurement of glyoxalase gene expression. Biochem. Soc. Trans. 42, 495 – 499.
  • Rabbani, N. and Thornalley, P.J. (2014) Dicarbonyl proteome and genome damage in metabolic and vascular disease.Biochem. Soc. Trans. 42, 425 – 432.
  • Ahmed, U.,Rabbani, N. and Thornalley, P.J. (2014) Possible role of methylglyoxal and glyoxalase in arthritis. Biochem. Soc. Trans. 42, 538 – 542.
  • Geoffrion, M., Du, X., Irshad, Z., Vanderhyden, B.C., Courville, K., Sui, G., D’Agati, V.D., Ott-Braschi, S., Rabbani, N., Thornalley, P.J., Brownlee, M. and Milne, R.W. (2014) Differential effects of glyoxalase 1 over expression on diabetic atherosclerosis and renal dysfunction in streptozotocin-treated apolipoprotein E-deficient mice. Physiological Reports 2, e12043.
  • Rabbani, N. and Thornalley, P.J. (2014) Measurement of methylglyoxal by stable isotopic dilution analysis LC-MS/MS with corroborative prediction in physiological samples. Nature Protocols 9, 1969 – 1979.
  • Godfrey, L., Yamada-Fowler, N., Thornalley, P.J. and Rabbani, N. (2014) Arginine-directed glycation and decreased HDL plasma concentration and functionality. Nutrition and Diabetes 4, e134.
  • Rabbani N. and Thornalley P.J. (2014) Glycation- and/or Polyol Pathway-inducing Complications. Reference Module in Biomedical Sciences. Elsevier, 1 – 7.

  • 2015

  • Rabbani, N. and Thornalley, P.J. (2015) The hidden complexities in measurement of fructosyl-lysine and advanced glycation endproducts for risk prediction of vascular complications of diabetes. Diabetes 64, 9 -11
  • Rabbani, N. and Thornalley, P.J. (2015) Dicarbonyl stress in cell and tissue dysfunction contributing to ageing and disease. Biochem. Biophys. Res. Commun. 458, 221-226, 2015.
  • Ahmed, U., Savage, R.S., Anwar, M.M., Costa, M.L., Filer, A., Raza, K., Watts, R.A., Winyard, P.G., Tarr, J., Haigh, R.C., Thornalley, P.J. and Rabbani, N. (2015) Biomarker combination detects early-stage and discriminates osteoarthritis, rheumatoid arthritis and other inflammatory joint disease. Scientific Reports 5: 9259.
  • Waris, S., Winklhofer-Roob, B.M., Roob, J.M., Fuchs, S., Sourij, H., Rabbani, N. and Thornalley, P.J. (2015) Increased dicarbonyl glycation and oxidation adducts of deoxyguanosine in plasma and urine of patients with type 2 diabetes and link to diabetic nephropathy. J. Diabetes Res, 915486, 1 – 10.
  • Duivenvoorde, L.P.M., van Schothorst, E. M., Derous, D., van der Stelt, I., Masania, J., Rabbani, N., Thornalley, P.J. and Keijer, J.  (2015) Oxygen restriction as challenge test reveals early high-fat-diet-induced changes in glucose and lipid metabolism. Pflugers Arch – Eur J Physiol 467, 1179–1193
  • Xue, M., Momiji, H., Rabbani, N., Bretschneider, T., Rand, D.A.and Thornalley, P.J. (2015) Frequency modulated translocational oscillations of Nrf2 – a transcription factor functioning like a wireless sensor. Biochem. Soc. Trans.43, 669–673.
  • Xue, M., Momiji, H., Rabbani, N., Barker, G., Shmygol, A., Bretschneider, T., Rand, D.A.and Thornalley, P.J. (2015) Frequency modulated translocational oscillations of Nrf2 mediate the ARE cytoprotective transcriptional response. Antioxidants & Redox Signalling 23, 613 – 629.
  • Ahmed, U., Thornalley, P.J. and Rabbani, N. (2015) Developing a plasma/serum-based biochemical assay for diagnosing early-stage arthritis. Biomarkers in Medicine 9, 943 – 945.
  • Ahmed, U., Thornalley, P.J. and Rabbani, N. (2015) Factors influencing the development and effectiveness of biomarkers in rheumatoid arthritis and osteoarthritis. Internat. J. Clin. Rheumatol. 10, 313–316

  • 2016

  • Zhang, F., Masania, J., Anwar, A., Xue, M., Zehnder, D., Kanji, H., Rabbani, N. and Thornalley, P.J. (2016) The uremic toxin oxythiamine causes functional thiamine deficiency in end-stage renal disease by inhibiting transketolase activity. Kidney Internat. 90, 396 – 403.
  • Xue, M., Weickert, M.O., Qureshi, S., Kandala, N.-B., Anwar, A., Waldron, M., Shafie, A., Messenger, D., Fowler, M., Jenkins, G., Rabbani, N.and Thornalley, P.J. (2016)Improved glycemic control and vascular function in overweight and obese subjects by glyoxalase 1 inducer formulation. Diabetes 65, 2282 – 2294.
  • Masania, J., Malczewska-Malec, M., Razny, U., Goralska, J., Zdzienicka, A., Kiec-Wilk, B., Gruca, A., Stancel-Mozwillo, J., Dembinska-Kiec, A., Rabbani, N., Thornalley, P.J. (2016) Dicarbonyl stress in clinical obesity. Glycoconjugate J. 33, 581-589.
  • Rabbani, N., Xue, M. and Thornalley, P.J. (2016) Dicarbonyl and glyoxalase in disease mechanisms and clinical therapeutics. Glycoconjugate J. 33, 513 – 525.
  • Rabbani, N., Ashour, A. and Thornalley, P.J. (2016) Mass spectrometric determination of advanced glycation in biology. Glycoconjugate J. 33, 553-568.
  • Rabbani, N., Xue, M. and Thornalley, P.J. (2016) Methylglyoxal-induced dicarbonyl stress in ageing and disease – first steps towards glyoxalase 1-based treatments. Clin. Sci. 130, 1677–1696
  • Rabbani, N. and Thornalley, P.J. (2016) Glycation of proteins. In: Analysis of Post-Translational Modifications Using Mass Spectrometry (Griffiths, J.R. and Unwin, R.D., eds.), Wiley, Holboken, USA, 307-332.
  • Ahmed, U., Anwar, A., Savage, R.S., Thornalley, P.J. and Rabbani, N. (2016) Application of protein glycation, oxidation and nitration for early-stage diagnosis and severity of osteoarthritis and other arthritic disease. Arthritis Research & Therapy 18:250
  • Shafie, A., Xue, M., Barker, G., Zehnder, D., Thornalley, P.J. and Rabbani, N. (2016) Re-appraisal of putative glyoxalase 1 deficient mouse and dicarbonyl stress on embryonic stem cells in vitro. Biochem. J. 473, 4255–4270.
  • Anwar, A., Marini, M., Abruzzo, P.M., Bolotta, A., Ghezzo, A., Visconti, P., Thornalley, P.J.and Rabbani, N. (2016)Quantitation of plasma thiamine, related metabolites and plasma protein oxidative damage markers in children with autism spectrum disorder and healthy controls. Free Radical Research 50. sup1, S85 – S90.
  • Stratmann, B., Engelbrecht, B., Espelage, B.C., Klusmeier, N., Tiemann, J., Gawlowski, T.,  Mattern, Y., Eisenacher, M., Meyer, H.E., Rabbani, N., Thornalley, P.J., Tschoepe, D., Poschmann, G. and Stühler, K. (2016) Glyoxalase 1-knockdown in human aortic endothelial cells – effect on the proteome and endothelial function. Scientific Reports 6, 37737.

  • 2017

  • Bernd Stratmann, Bernhard Goldstein, Paul J. Thornalley, Naila Rabbani and Diethelm Tschoepe (2017) Intracellular Accumulation of Methylglyoxal by Glyoxalase 1 Knock Down Alters Collagen Homoeostasis in L6 Myoblasts. Internat. J. Molec. Sci. 18, 480.
  • Urszula Razny, Joanna Goralska, Anna Zdzienicka, Danuta Fedak, Jinit Masania, Naila Rabbani, Paul Thornalley, Dorota Pawlica-Gosiewska, Katarzyna Gawlik, Aldona Dembinska-Kiec, Bogdan Solnica, Malgorzata Malczewska-Malec (2017)Relation of protein glycation, oxidation and nitration with osteocalcin level in obese subjects. Biochimica Polonica Acta 64, 415 – 422.
  • Rowan, S., Jiang, S., Korem, T., Szymanski, J., Chang, M.-L., Szelog, J., Cassalman, C., Dasuri, K., McGuire, C., Nagai, R., Du, X.-L., Brownlee, M., Rabbani, N., Thornalley, P.J., Baleja, J., Clish, C., Smith, D., Segal, E. and Taylor, A. (2017) Involvement of a gut-retina axis in protection against dietary glycemia induced age-related macular degeneration. Proc. Natl. Acad. Sci. USA 114, E4472–E4481.
  • Xue, Mingzhan, Shafie, Alaa, Qaiser, Talha, Rajpoot, Nasir M, Kaltsas, G, James S, Gopalakrishnan, K., Fisk, A., Dimitriadis, Georgios K., Grammatopoulos, Dimitris K., Rabbani, Naila, Thornalley, Paul J. and Weickert, M. O. (2017) Glyoxalase 1 copy number variation in patients with well differentiated gastroentero-pancreatic neuroendocrine tumours (GEP-NET). Oncotarget 8, 76961-76973.

  • 2018

  • Rabbani, N., Xue, M., Weickert, M.O. and Thornalley, P.J. (2018) Multiple roles of glyoxalase 1-mediated suppression of methylglyoxal glycation in cancer biology – involvement in tumour suppression, tumour growth, multidrug resistance and target for chemotherapy. Seminars in Cancer Biology 49, 83 – 93.
  • N. Rabbani and P. J. Thornalley (2018). Advanced glycation endproducts in the pathogenesis of chronic kidney disease. Kidney International, 93, 803–813
  • Rabbani, N., Xue, M., Weickert, M.O. and Thornalley, P.J. (2018) Multiple roles of glyoxalase 1-mediated suppression of methylglyoxal glycation in cancer biology – involvement in tumour suppression, tumour growth, multidrug resistance and target for chemotherapy. Seminars in Cancer Biology 49, 83 – 93.
  • Chung‐Jung Chiu, Naila Rabbani, Sheldon Rowan, Min-Lee Chang, Sherilyn Sawyer, Frank Hu, Walter Willett, Paul J. Thornalley, Attia Anwar, Liliana Bar, Jae H. Kang, Allen Taylor (2018) Studies of advanced glycation end products and oxidation biomarkers for type 2 diabetes Biofactors 44, 281 – 288.
  • Christos Spanos, Elaina M. Maldonado, Ciarán P. Fisher, Petchpailin Leenutaphong, Ernesto Oviedo-Orta, David Windridge, Francisco J. Salguero, Alexandra Bermúdez-Fajardo, Mark E. Weeks, Caroline Evans Bernard M. Corfe, Naila Rabbani, Paul J. Thornalley, Michael H. Miller, Huan Wang, John F. Dillon, Alberto Quaglia7, Anil Dhawan, Emer Fitzpatrick and J. Bernadette Moore (2018) Proteomic identification and characterization of hepatic glyoxalase 1 dysregulation in non-alcoholic fatty liver disease, Proteome Science 16, 4.
  • Anwar, A., Abruzzo, P.M., Pasha, S., Rajpoot, K., Bolotta, A., Ghezzo, A., Marini, M., Posar, A., Visconti, P., Thornalley, P.J. and Rabbani, N. (2018) Advanced glycation endproducts, dityrosine and arginine transporter dysfunction in autism – a source of biomarkers for clinical diagnosis Molecular Autism 9, 3.
  • Catherine Legrand, Usman Ahmed, Attia Anwar, Kashif Rajpoot, Sabah Pasha, Cécile Lambert, Rose K. Davidson, Ian M. Clark, Paul J. Thornalley, Yves Henrotin and Naila Rabbani (2018) Glycation marker glucosepane increases with the progression of osteoarthritis and correlates with morphological and functional changes of cartilage in vivo Arthritis Research & Therapy 20, 131.
  • Hariton, F., Xue, M., Rabbani, N., Fowler, M. and Paul J Thornalley. (2018) Sulforaphane delays fibroblast senescence by curbing cellular glucose uptake, increased glycolysis and oxidative damage. Oxidative Medicine & Longevity. Oxidative Medicine & Longevity 2018, 5642148.

  • 2019

  • Rabbani, N. and Thornalley, P.J. (2019) Glyoxalase 1 modulation in obesity and diabetes. Antioxidants and Redox Signalling 30, 354 – 374.
  • Irshad, Z., Xue, M., Ashour, A., Pasha, S., Larkin, J.R., Thornalley, P.J. and Rabbani, N. (2019) Activation of the unfolded protein response of endothelial cells in high glucose by methylglyoxal. Scientific Reports 9, 7889.
  • Rabbani, N. and Thornalley, P.J. (2019) Autism – In search of mechanistic biomarkers, Journal Autism and Developmental Disorders 17, 15 – 23.
  • Rabbani, N. and Thornalley, P.J. (2019) Hexokinase-2 mediated glycolytic overload in diabetes and ischemia reperfusion injury. Trends in Endocrinol. Metab. 30, 419 – 431.
  • Jinit Masania, Gernot Faustmann, Attia Anwar, Hildegard Hafner-Giessauf, Nasir Rajpoot, Johanna Grabher, Kashif Rajpoot, Beate Tiran, Barbara Obermayer-Pietsch, Brigitte Winklhofer-Roob, Johannes Roob, Naila Rabbani and Paul J. Thornalley. (2019) Urinary metabolomic markers of protein glycation, oxidation and nitration in early-stage decline in metabolic, vascular and renal health. Oxidative Medicine and Cellular Longevity, Volume 2019, 4851323.

  • 2020

  • Naila Rabbani and Paul J. Thornalley (2020) Reading the patterns of proteome damage by glycation, oxidation and nitration – quantitation by stable isotopic dilution analysis LC-MS/MS. Essays Biochem 64, 169 -183
  • S. Rowan, S. Jiang, M-L Chang, J. Volkin, C. Cassalman, K. M. Smith, M. D. Streeter, D. A. Spiegel, C. Moreira-Neto, N. Rabbani, P. J. Thornalley, D.E. Smith, N. K. Waheed, A. Taylor (2020) A low glycemic diet protects disease-prone Nrf2-deficient mice against age-related macular degeneration. Free Radical Biology and Medicine 150, 75 – 86.
  • Naila Rabbani, Maryam Al-Motawa and Paul Thornalley (2020) Protein Glycation in Plants—An Under-Researched Field with Much Still to Discover. Internat. J. Molec. Sci. 21, 3942.
  • E. Feskens, L. Brennan, P. Dussort, M. Flourakis, L. M. E. Lindner, D. Mela, N. Rabbani, W. Rathmann, F. Respondek, C. Stehouwer, S. Theis, P.J. Thornalley, S. Vinoy (2020) Potential markers of dietary glycemic exposures for sustained dietary interventions in populations without diabetes. Advances in Nutrition 11, 1221 – 1236.
  • B. Perkin, N. Rabbani, A. Weston, A. Gotaswari, J. Lee, L. Lovblom, N. Cardinez, P.J. Thornalley (2020) High fractional excretion of glycation adducts is associated with subsequent early decline in renal function in type 1 diabetes, (* joint first authors) Sci. Rep. 10, 12709.
  • Amal Ashour, Mingzhan Xue, Maryam Al-Motawa, Paul J. Thornalley and Naila Rabbani, (2020) Glycolytic overload-driven dysfunction of periodontal ligament fibroblasts in high glucose concentration, corrected by glyoxalase 1 inducer. BMJ Open Diab Res Care 8: e001458.
  • Maryam Al-Motawa, Hafsa Abbas, Patrick Wijten, Alberto de la Fuente, Mingzhan Xue, Naila Rabbani and Paul J. Thornalley (2020) Vulnerabilities of the SARS-CoV-2 virus to proteotoxicity – opportunity for repurposed chemotherapy of COVID-19 infection. Frontiers of Pharmacology 11, 1579.

  • 2021

  • Naila Rabbani and Paul J Thornalley (2021) Protein glycation – emerging evidence as biomarkers of metabolic dysfunction and early-stage decline in health in the era of precision medicine. Redox Biology 42, 101920
  • Naila Rabbani, Mingzhan Xue and Paul J. Thornalley (2021) Dicarbonyl stress, protein glycation and the unfolded protein response Glycoconjugate J. 38, 331 – 334.
  • Naila Rabbani, Mingzhan Xue, Martin O. Weickert and Paul J. Thornalley (2021) Reversal of insulin resistance in overweight and obese subjects by trans-resveratrol and hesperetin combination – link to dysglycemia, blood pressure, dyslipidemia and low-grade inflammation. Nutrients 13, 2374

  • 2022

  • Muhanad Alhujaily, Hafsa Abbas, Mingzhan Xue, Alberto de la Fuente, Naila Rabbani, Paul Thornalley (2022) Studies of glyoxalase 1-linked multidrug resistance reveal glycolysis-derived reactive metabolite, methylglyoxal, is a common contributor in cancer chemotherapy targeting the spliceosome, Frontiers in Oncology 4413
  • Naila Rabbani Mingzhan Xue,and Paul J. Thornalley (2022) Hexokinase-2-linked glycolytic overload and unscheduled glycolysis – driver of insulin resistance and development of type 2 diabetes and vascular complications of diabetes. Internat. J. Molec. Sci. 23, 2165.
  • Naila Rabbani and Paul J. Thornalley (2022) Emerging glycation-based therapeutics – glyoxalase 1 inducers and glyoxalase 1 inhibitors. Internat. J. Molec. Sci. 23, 2453.
  • Naila Rabbani (2022) Methylglyoxal and glyoxalase 1 – a metabolic stress pathway linking hyperglycemia to the unfolded protein response and vascular complications of diabetes Clin. Sci. 136 (11): 819–824.
  • Naila Rabbani (2022) AGEomics biomarkers and machine learning – realising the potential of protein glycation in clinical diagnostics; Internat. J. Mol. Sci. 23 (9), 4584
  • Rabbani, N. and Thornalley, P.J. (2022) An Introduction to Special Issue “Protein Glycation in Food, Nutrition, Health and Disease”. Internat. J. Molec. Sci. 23, 13053.

  • 2023

  • Rabbani, N., Adaikalakoteswari, A., Larkin, J.R., Panagiotopoulos, S., MacIsaac, R.J., Yue, D.K., Fulcher, G.R., Roberts, M., Thomas, M., Ekinci, E. and Thornalley, P.J. (2023) Analysis of serum advanced glycation endproducts reveals methylglyoxal-derived advanced glycation MG-H1 free adduct is a risk marker in non-diabetic and diabetic chronic kidney disease. Internat. J. Molec. Sci. 24, 152.
  • Masania, J., Witjen, P., Keipert, S., Ost, M., Klaus, S., Rabbani, N. and Thornalley, P.J. (2023) Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle. Redox Biology 59, 102574
  • Al-Saei, A.N.J.M., Eldine, W.N., Rajpoot, K., Arshad, N., Al-Shammari, A.R., Kamal, M., Al-Shabeeb Akil, A., Fakhro, K.A., Thornalley, P.J. and Rabbani, N. (2023) Validation of plasma protein glycation and oxidation biomarkers for the diagnosis of autism. Molecular Psychiatry, https://doi.org/10.1038/s41380-023-02357-9.

  • 2024

  • Xue, M., Rabbani, N. and Thornalley, P.J. (2024) Increased cellular protein modification by methylglyoxal activates three sensors of the unfolded protein response. Redox Biol. 65, 103025.
  • Rabbani, N. and Thornalley, P.J. (2024) Hexokinase-linked glycolytic overload and unscheduled glycolysis in hyperglycemia-induced pathogenesis in insulin resistance, beta-cell glucotoxicity and diabetic vascular complications. Frontiers in Endocrinology 14 https://doi.org/10.3389/fendo.2023.1268308