Bench to bedside research – development of GlucoRegulate
The time I spent away from children was dedicated to translational research. In 2014, I had the opportunity to be part of a research team led by Professor Paul J. Thornalley at the University of Warwick. Our goal was to develop a precision food supplement capable of inducing the glyoxalase 1 (Glo1) protein. The Glo1 system plays a crucial role in countering glucose stress (also known as dicarbonyl stress) and maintaining normal metabolic function. The study was successfully completed and published in the journal Diabetes.
The study titled “Improved Glycemic Control and Vascular Function in Overweight and Obese Subjects by Glyoxalase 1 Inducer Formulation”, published in Diabetes (August 2016), investigates the effects of a dietary supplement combining trans-resveratrol (tRES) and hesperetin (HESP) on metabolic and vascular health in overweight and obese individuals.
🔬 Study Overview
- Objective: To assess whether inducing the enzyme glyoxalase 1 (Glo1) can improve glycemic control and vascular function.
- Methodology: A randomized, placebo-controlled crossover trial involving 29 overweight and obese participants.
- Intervention: Participants received a coformulation of tRES and HESP, known to synergistically induce Glo1 expression.
🩺 Key Findings
- Glo1 Activity: The tRES-HESP combination increased Glo1 expression and activity by 27% (P < 0.05).
- Glycemic Control:
- Fasting plasma glucose decreased by up to 28% (P < 0.01).
- Postprandial glucose levels dropped by up to 40% (P < 0.03).
- Oral glucose insulin sensitivity improved by up to 41% (increase of 42 mL·min⁻¹·m⁻², P < 0.02).
- Vascular Health:
- Enhanced brachial artery flow-mediated dilation.
- Reduced levels of soluble intercellular adhesion molecule-1 by 10% (P < 0.01), a marker of vascular inflammation.
- Metabolic Effects: Significant reductions in plasma methylglyoxal (-37%, P < 0.05) and total body methylglyoxal-protein glycation (-14%, P < 0.01).
💡 Conclusions
The combination of tRES and HESP effectively enhances Glo1 activity, leading to improved glycemic control and vascular function in overweight and obese individuals. This suggests potential for the tRES-HESP coformulation (GlucoRegulate) as a therapeutic strategy for metabolic and vascular health improvement.
For more detailed information, you can access the full study here: Diabetes Journals.
Marketing of GlucoRegulate by https://glovitality.com/
Managing blood sugar levels is crucial for overall health, especially for those at risk of type 2 diabetes, insulin resistance, or metabolic syndrome. GlucoRegulate, developed by GloVitality, offers a natural supplement designed to support blood glucose regulation and improve insulin sensitivity.
🌿 What Is GlucoRegulate?
GlucoRegulate is a patented supplement combining two potent plant-based compounds: trans-resveratrol and hesperetin. Resveratrol, found in red grapes and berries, is known for its antioxidant properties. However, its effectiveness is limited due to poor absorption in the body. Hesperetin, derived from citrus fruits, enhances the bioavailability of resveratrol improved absorption and increased the health benefits by up to 79 times making the combination significantly more effective than resveratrol alone.
🔬 The Science Behind GlucoRegulate
The key to GlucoRegulate’s effectiveness lies in its ability to induce the glyoxalase 1 (Glo1) enzyme by activating Nrf2. This system helps detoxify harmful byproducts of sugar metabolism, reducing oxidative stress and inflammation—factors that contribute to insulin resistance and high blood sugar levels.
Clinical studies have shown that daily intake of GlucoRegulate:
- Improves blood glucose control
- Enhances insulin sensitivity
- Reduces post-meal glucose spikes
- Provides anti-inflammatory benefits
- Is safe and well-tolerated
Remarkably, GlucoRegulate has been found to improve insulin sensitivity more effectively than moderate to high-intensity exercise, making it a valuable option for individuals who may have difficulty engaging in regular physical activity.
💊 How to Use GlucoRegulate
GlucoRegulate is easy to incorporate into your daily routine. Simply take one capsule per day. Each bottle contains a 30-day supply. For optimal results, combine GlucoRegulate with a balanced diet and regular exercise.
🧪 Quality and Purity
GlucoRegulate is manufactured in the UK in a GMP-certified facility, ensuring the highest quality standards. The supplement contains over 99% pure trans-resveratrol and over 98% pure hesperetin, with third-party lab testing to guarantee purity and potency.
🌟 Customer Testimonials
Users of GlucoRegulate have reported significant improvements in their health:
“In 2 months, it has considerably improved my blood glucose levels. Highly recommended.” – Arfa Imran
“Used this supplement and definitely felt a difference. Feels good taking something natural and safe.” – Sara
“My kidney pain is gone, and I feel so energized. Blood sugar levels have come down.” – Saadia
🛒 Try GlucoRegulate Today
Experience the benefits of GlucoRegulate for yourself. Visit glovitality.com to learn more and place your order. Free delivery is available on orders over £50.